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KMID : 0903520090520040342
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 4 p.342 ~ p.345
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Inhibitory Effects of Stilbene Glucoside Isolated from the Root of Polygonum multiflorum on Tyrosinase Activity and Melanin Biosynthesis
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Kim Ju
Kim Jung-Hoon
Jeung Eun-Sun
Park In-Sun
Choe Chung-Hyeon
Kwon Tae-Ho
Yu Kang-Yeol
Jeong Seung-Il
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Abstract
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As part of efforts to discover phytochemicals that inhibit melanin biosynthesis, we screened (E)-2,3,5,4\’-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) isolated from Polygonum multiflorum. THSG dose-dependently inhibited tyrosinase activity, with an ID50 value of 100 μg/mL. THSG also potently inhibited melanin production in B16 melanoma cells induced by forskolin, an inducer of melanogenesis, with ID50 of 1-10 μg/mL. THSG may therefore reduce melanogenesis.
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KEYWORD
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melanogenesis, Polygonum multiflorum, (E)-2,3,5,4´-tetrahydroxystilbene-2-O-β-D-glucoside
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